Hyperpolarised carbon-13 magnetic resonance spectroscopy with [1-13C]ethylpyruvate as a preclinical modality for detecting MS-like lesions and their response to fingolimod treatment in the focal experimental autoimmune encephalomyelitis rat model of multiple sclerosis

Thesis

Multiple sclerosis (MS) is a demyelinating, immune-mediated disease of the central nervous system characterised by both acute episodes of neurological dysfunction and long-term neurodegeneration.

Diagnosis and monitoring rely heavily on imaging, with magnetic resonance imaging (MRI) the present gold-standard modality. Current MRI techniques, however, have poor sensitivity for monitoring the development of pre-demyelinated lesions and in assessing treatment response.

In MS l...

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Authors: Healicon, R

• Type of award: MSc by Research
• Level of award: Masters
• Awarding institution: University of Oxford
• Language: English
• Keywords: fingolimod; Multiple sclerosis; magnetic resonance imaging; 13C; focal experimental autoimmune encephalomyelitis
• Subjects: Multiple sclerosis; Magnetic resonance imaging