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A whole genome association study in multiple sclerosis patients from north Portugal.

Abstract:
Genetic factors are known to influence susceptibility to multiple sclerosis (MS) but the genes involved are largely undefined. Here, we report an association study based on 200 patients and 200 controls from the Porto region in Portugal. A total of 3974 markers were successfully typed from which we have identified 46 markers showing evidence of association. When compared to a physical map three regions were found with two of these markers less than 1.5 Mb apart: chromosomes 6p21.3 (the MHC region), 6q14.1 and 7q34.

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Authors


Martins Silva, B More by this author
Thorlacius, T More by this author
Benediktsson, K More by this author
Pereira, C More by this author
Fossdal, R More by this author
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Journal:
Journal of neuroimmunology
Volume:
143
Issue:
1-2
Pages:
116-119
Publication date:
2003-10-05
DOI:
EISSN:
1872-8421
ISSN:
0165-5728
URN:
uuid:725e2341-4678-4eec-9130-7cccff707640
Source identifiers:
252266
Local pid:
pubs:252266

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