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Journal article

Antibody landscapes after influenza virus infection or vaccination.

Abstract:

We introduce the antibody landscape, a method for the quantitative analysis of antibody-mediated immunity to antigenically variable pathogens, achieved by accounting for antigenic variation among pathogen strains. We generated antibody landscapes to study immune profiles covering 43 years of influenza A/H3N2 virus evolution for 69 individuals monitored for infection over 6 years and for 225 individuals pre- and postvaccination. Upon infection and vaccination, titers increased broadly, includi...

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Publication status:
Published

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Publisher copy:
10.1126/science.1256427

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Publisher:
American Association for the Advancement of Science
Journal:
Science (New York, N.Y.)
Volume:
346
Issue:
6212
Pages:
996-1000
Publication date:
2014-11-05
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
URN:
uuid:725ddba9-3b69-4504-99cc-add9e94a9645
Source identifiers:
491768
Local pid:
pubs:491768

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