- Abstract:
-
We introduce the antibody landscape, a method for the quantitative analysis of antibody-mediated immunity to antigenically variable pathogens, achieved by accounting for antigenic variation among pathogen strains. We generated antibody landscapes to study immune profiles covering 43 years of influenza A/H3N2 virus evolution for 69 individuals monitored for infection over 6 years and for 225 individuals pre- and postvaccination. Upon infection and vaccination, titers increased broadly, includi...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1126/science.1256427
-
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- Publisher:
- American Association for the Advancement of Science
- Journal:
- Science (New York, N.Y.)
- Volume:
- 346
- Issue:
- 6212
- Pages:
- 996-1000
- Publication date:
- 2014-11-05
- DOI:
- EISSN:
-
1095-9203
- ISSN:
-
0036-8075
- URN:
-
uuid:725ddba9-3b69-4504-99cc-add9e94a9645
- Source identifiers:
-
491768
- Local pid:
- pubs:491768
- Language:
- English
- Keywords:
- Copyright date:
- 2014
Journal article
Antibody landscapes after influenza virus infection or vaccination.
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