Thesis
Studies on enzymes mechanism and selectivity using synthetic substrate analogues
- Abstract:
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Organic chemistry is a valuable tool for studying enzyme mechanisms. Upon incubation with a specific enzyme, synthetic substrate analogues labeled with heavy atoms or carrying extra functional groups can provide mechanistic insights. In the present work, new compounds were synthesised in order to study the mechanism and substrate selectivity of two enzymes: human γ-butyrobetaine hydroxylase and bacterial carboxymethylproline synthase.
γ-Butyrobetaine hydroxylase (BBOX) is an Fe(II) a...
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Funding
Bibliographic Details
- Publication date:
- 2012
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
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uuid:724f92a5-891c-4269-961b-9c340a504ddd
- Local pid:
- ora:9633
- Deposit date:
- 2014-12-19
Terms of use
- Copyright holder:
- Henry, L
- Copyright date:
- 2012
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