- Abstract:
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Organic chemistry is a valuable tool for studying enzyme mechanisms. Upon incubation with a specific enzyme, synthetic substrate analogues labeled with heavy atoms or carrying extra functional groups can provide mechanistic insights. In the present work, new compounds were synthesised in order to study the mechanism and substrate selectivity of two enzymes: human γ-butyrobetaine hydroxylase and bacterial carboxymethylproline synthase.
γ-Butyrobetaine hydroxylase (BBOX) is an Fe(II) a...
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- Publication date:
- 2012
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
- URN:
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uuid:724f92a5-891c-4269-961b-9c340a504ddd
- Local pid:
- ora:9633
- Language:
- English
- Keywords:
- Subjects:
- Copyright holder:
- Luc Henry
- Copyright date:
- 2012
Thesis
Studies on enzymes mechanism and selectivity using synthetic substrate analogues
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