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Studies on enzymes mechanism and selectivity using synthetic substrate analogues

Abstract:

Organic chemistry is a valuable tool for studying enzyme mechanisms. Upon incubation with a specific enzyme, synthetic substrate analogues labeled with heavy atoms or carrying extra functional groups can provide mechanistic insights. In the present work, new compounds were synthesised in order to study the mechanism and substrate selectivity of two enzymes: human γ-butyrobetaine hydroxylase and bacterial carboxymethylproline synthase.

γ-Butyrobetaine hydroxylase (BBOX) is an Fe(II) a...

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author

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Role:
Supervisor
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Funding agency for:
Henry, L
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:724f92a5-891c-4269-961b-9c340a504ddd
Local pid:
ora:9633
Deposit date:
2014-12-19

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