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Arenavirus glycan shield promotes neutralizing antibody evasion and protracted infection.

Abstract:

Arenaviruses such as Lassa virus (LASV) can cause severe hemorrhagic fever in humans. As a major impediment to vaccine development, delayed and weak neutralizing antibody (nAb) responses represent a unifying characteristic of both natural infection and all vaccine candidates tested to date. To investigate the mechanisms underlying arenavirus nAb evasion we engineered several arenavirus envelope-chimeric viruses and glycan-deficient variants thereof. We performed neutralization tests with sera...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.ppat.1005276

Authors


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Klaus Tschira Stiftung More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Pathogens Journal website
Volume:
11
Issue:
11
Pages:
Article: e1005276
Publication date:
2015-11-20
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
URN:
uuid:724efbc5-247e-4e24-9c84-f527a926919e
Source identifiers:
588632
Local pid:
pubs:588632
Language:
English

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