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Wolbachia stimulates immune gene expression and inhibits plasmodium development in Anopheles gambiae.

Abstract:

The over-replicating wMelPop strain of the endosymbiont Wolbachia pipientis has recently been shown to be capable of inducing immune upregulation and inhibition of pathogen transmission in Aedes aegypti mosquitoes. In order to examine whether comparable effects would be seen in the malaria vector Anopheles gambiae, transient somatic infections of wMelPop were created by intrathoracic inoculation. Upregulation of six selected immune genes was observed compared to controls, at least two of whic...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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10.1371/journal.ppat.1001143

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Institution:
University of Oxford
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Institution:
University of Oxford
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Institution:
University of Oxford
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University of Oxford
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Pathog Journal website
Volume:
6
Issue:
10
Pages:
Article: e1001143
Publication date:
2010-01-01
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
URN:
uuid:7245de3e-903a-4b8f-b425-443f999a18ba
Source identifiers:
163861
Local pid:
pubs:163861

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