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Advances in high-capacity extrachromosomal vector technology: episomal maintenance, vector delivery, and transgene expression.

Abstract:

Recent developments in extrachromosomal vector technology have offered new ways of designing safer, physiologically regulated vectors for gene therapy. Extrachromosomal, or episomal, persistence in the nucleus of transduced cells offers a safer alternative to integrating vectors which have become the subject of safety concerns following serious adverse events in recent clinical trials. Extrachromosomal vectors do not cause physical disruption in the host genome, making these vectors safe and ...

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Publication status:
Published

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Publisher copy:
10.1038/mt.2008.156

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
Journal:
Molecular therapy : the journal of the American Society of Gene Therapy
Volume:
16
Issue:
9
Pages:
1525-1538
Publication date:
2008-09-05
DOI:
EISSN:
1525-0024
ISSN:
1525-0016
URN:
uuid:723258bd-8ecd-43bc-a27d-9a0c1d6879e3
Source identifiers:
113362
Local pid:
pubs:113362

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