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Dickkopf-3 is upregulated in osteoarthritis and has a chondroprotective role

Abstract:

Dickkopf-3 (Dkk3) is a non-canonical member of the Dkk family of Wnt antagonists and its upregulation has been reported in microarray analysis of cartilage from mouse models of osteoarthritis (OA). In this study we assessed Dkk3 expression in human OA cartilage to ascertain its potential role in chondrocyte signaling and cartilage maintenance.Dkk3 expression was analysed in human adult OA cartilage and synovial tissues and during chondrogenesis of ATDC5 and human mesenchymal stem cells. The r...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.joca.2015.11.021

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
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Publisher:
Elsevier Ltd. Publisher's website
Journal:
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society Journal website
Volume:
24
Issue:
5
Pages:
883-891
Publication date:
2015-12-12
Acceptance date:
2015-11-24
DOI:
EISSN:
1522-9653
ISSN:
1063-4584
URN:
uuid:722b52d9-79ae-4dd5-8cc1-5fbd3202a7b9
Source identifiers:
589083
Local pid:
pubs:589083
Paper number:
5
Language:
English
Keywords:

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