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Stochastic Models and Simulation of Ion Channel Dynamics

Abstract:

The behaviour of ion channels within cardiac and neuronal cells is intrinsically stochastic in nature. When the number of channels is small this stochastic noise is large and can have an impact on the dynamics of the system which is potentially an issue when modelling small neurons and drug block in cardiac cells. While exact methods correctly capture the stochastic dynamics of a system they are computationally expensive, restricting their inclusion into tissue level models and so approximati...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher version

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Publisher copy:
10.1016/j.procs.2010.04.178

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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Role:
Author
More by this author
Institution:
University of Oxford
Role:
Author
Publisher:
Elsevier B.V. Publisher's website
Journal:
ICCS 2010 - INTERNATIONAL CONFERENCE ON COMPUTATIONAL SCIENCE, PROCEEDINGS Journal website
Volume:
1
Issue:
1
Pages:
1581-1590
Publication date:
2010-01-01
DOI:
EISSN:
1877-0509
ISSN:
1877-0509
URN:
uuid:722567f1-9a54-4255-87de-65d5645358ab
Source identifiers:
301850
Local pid:
pubs:301850

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