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Optimal sequencing strategies for surveying molecular genetic diversity.

Abstract:

Two commonly used measures of genetic diversity for intraspecies DNA sequence data are based, respectively, on the number of segregating sites, and on the average number of pairwise nucleotide differences. Expressions are derived for their variance in the presence of intragenic recombination for a panmictic population of fixed size that is at neutral equilibrium at the region sequenced. We show that, in contrast to the slow decrease in variance with increasing sample size, if the recombinatio...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
Journal:
Genetics
Volume:
144
Issue:
3
Pages:
1247-1262
Publication date:
1996-11-01
EISSN:
1943-2631
ISSN:
0016-6731
Source identifiers:
69406
Language:
English
Keywords:
Pubs id:
pubs:69406
UUID:
uuid:7208169d-350a-4ac1-bc5f-848ec4a1f65a
Local pid:
pubs:69406
Deposit date:
2012-12-19

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