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Optimal sequencing strategies for surveying molecular genetic diversity.

Abstract:

Two commonly used measures of genetic diversity for intraspecies DNA sequence data are based, respectively, on the number of segregating sites, and on the average number of pairwise nucleotide differences. Expressions are derived for their variance in the presence of intragenic recombination for a panmictic population of fixed size that is at neutral equilibrium at the region sequenced. We show that, in contrast to the slow decrease in variance with increasing sample size, if the recombinatio...

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Publication status:
Published

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Authors


Pluzhnikov, A More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics, BHF Centre of Research Excellence, Biomedical Research Centre, MPLS, Statistics
Journal:
Genetics
Volume:
144
Issue:
3
Pages:
1247-1262
Publication date:
1996-11-05
EISSN:
1943-2631
ISSN:
0016-6731
URN:
uuid:7208169d-350a-4ac1-bc5f-848ec4a1f65a
Source identifiers:
69406
Local pid:
pubs:69406

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