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Journal article

Characterization of an in vivo concentration-effect relationship for piperaquine in malaria chemoprevention.

Abstract:

A randomized, placebo-controlled trial conducted on the northwest border of Thailand compared malaria chemoprevention with monthly or bimonthly standard 3-day treatment regimens of dihydroartemisinin-piperaquine. Healthy adult male subjects (N = 1000) were followed weekly during 9 months of treatment. Using nonlinear mixed-effects modeling, the concentration-effect relationship for the malaria-preventive effect of piperaquine was best characterized with a sigmoidal Emax relationship, where pl...

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Publication status:
Published

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Authors


Bergstrand, M More by this author
Karlsson, MO More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
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Publisher:
American Association for the Advancement of Science
Journal:
Science translational medicine
Volume:
6
Issue:
260
Pages:
260ra147
Publication date:
2014-10-05
DOI:
EISSN:
1946-6242
ISSN:
1946-6234
URN:
uuid:720402a6-ebf0-4ee0-af91-e7e67cea6e4d
Source identifiers:
488413
Local pid:
pubs:488413
Language:
English

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