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Journal article

DNA replication licensing in somatic and germ cells.

Abstract:

The DNA replication (or origin) licensing system ensures precise duplication of the genome in each cell cycle and is a powerful regulator of cell proliferation in metazoa. Studies in yeast, Drosophila melanogaster and Xenopus laevis have characterised the molecular machinery that constitutes the licensing system, but it remains to be determined how this important evolutionary conserved pathway is regulated in Homo sapiens. We have investigated regulation of the origin licensing factors Cdc6, ...

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Publisher copy:
10.1242/jcs.01503

Authors


Obermann, EC More by this author
Shreeram, S More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Primary Care Health Sciences
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Journal:
Journal of cell science
Volume:
117
Issue:
Pt 24
Pages:
5875-5886
Publication date:
2004-11-05
DOI:
EISSN:
1477-9137
ISSN:
0021-9533
URN:
uuid:71fed759-ab35-4dec-ad2a-24f076b7524e
Source identifiers:
387995
Local pid:
pubs:387995

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