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The role of the HNF4α enhancer in type 2 diabetes variants of the HNF4α enhancer are not a common cause of susceptibility to type 2 diabetes

Abstract:

The genetic causes of type 2 diabetes are not well understood. The disease has been linked to chromosome 20q12-q13.1 a region which harbors the transcription factor HNF4α. Mutations in the coding region of HNF4α cause maturity onset diabetes of the young, an autosomal dominant form of diabetes, but do not account for the linkage to this region. An enhancer element has recently been characterized 6 kb 5′ of the HNF4α P1 promoter containing binding sites for the transcription factors HNF1, HNF4...

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Role:
Author
Journal:
Molecular Genetics and Metabolism
Volume:
76
Issue:
2
Pages:
148-151
Publication date:
2002-01-01
DOI:
ISSN:
1096-7192
URN:
uuid:71fac0c0-1649-4b64-a93e-4ad593180217
Source identifiers:
94083
Local pid:
pubs:94083

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