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Journal article

Characterization of secreted and intracellular forms of a truncated hepatitis C virus E2 protein expressed by a recombinant herpes simplex virus.

Abstract:

A replication-defective herpes simplex virus type 1 (HSV-1) recombinant lacking the glycoprotein H (gH)-encoding gene and expressing a truncated form of the hepatitis C (HCV) E2 glycoprotein (E2-661) was constructed and characterized. We show here that cells infected with the HSV/HCV recombinant virus efficiently express the HCV E2-661 protein. Most importantly, cellular and secreted E2-661 protein were both readily detected by the E2-conformational mAb H53 and despite the high expression lev...

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Publication status:
Published

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Publisher copy:
10.1099/vir.0.18775-0

Authors


Tsitoura, E More by this author
Montoya, M More by this author
Laliotou, B More by this author
Aslanoglou, E More by this author
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Journal:
The Journal of general virology
Volume:
84
Issue:
Pt 3
Pages:
545-554
Publication date:
2003-03-05
DOI:
EISSN:
1465-2099
ISSN:
0022-1317
URN:
uuid:71f85b3f-8378-4a48-8cd6-4e82d923dfa3
Source identifiers:
19964
Local pid:
pubs:19964

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