Relationship between Mycobacterium tuberculosis Genotype and the Clinical Phenotype of Pulmonary and Meningeal Tuberculosis

Journal article

We used large sequence polymorphisms to determine the genotypes of 397 isolates of Mycobacterium tuberculosis from human immunodeficiency virus-uninfected Vietnamese adults with pulmonary (n = 235) or meningeal (n = 162) tuberculosis. We compared the pretreatment radiographic appearances of pulmonary tuberculosis and the presentation, response to treatment, and outcome of tuberculous meningitis between the genotypes. Multivariate analysis identified variables independently associated with gen...

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Authors: Thwaites, G; Caws, M; Chau, T; D'Sa, A; Lan, N

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: American Society for Microbiology
• Journal: Journal of Clinical Microbiology
• Volume: 46
• Issue: 4
• Pages: 1363-1368
• Publication date: 2008-04-02
• Acceptance date: 2008-02-04
• DOI: 10.1128/JCM.02180-07
• EISSN: 1098-660X
• ISSN: 0095-1137
• Pmid: 18287322
• Language: English
• Keywords: Antitubercular Agents; Humans; Phenotype; Middle Aged; Tuberculosis, Pulmonary; Adult; Journal Article; Polymorphism, Genetic; Disease Progression; Aged; SBTMR; Microbial Sensitivity Tests; Research Support, Non-U.S. Gov't; Genotype; Mycobacterium tuberculosis; Adolescent; Tuberculosis, Meningeal