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Contributions of the host microenvironment to cancer-induced bone disease.

Abstract:

The bone marrow provides a specialized and highly supportive microenvironment for tumor growth and development of the associated bone disease. It is a preferred site for breast and prostate cancer bone metastasis and the hematologic malignancy, multiple myeloma. For many years, researchers have focused upon the interactions between tumor cells and the cells directly responsible for bone remodeling, namely osteoclasts and osteoblasts. However, there is ever-increasing evidence for a multitude ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
Cancer research
Volume:
74
Issue:
6
Pages:
1625-1631
Publication date:
2014-03-05
DOI:
EISSN:
1538-7445
ISSN:
0008-5472
URN:
uuid:71f16255-412c-4240-ae2e-1a89ae63a4a3
Source identifiers:
451094
Local pid:
pubs:451094

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