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Journal article

Direct observation of distinct A/P hybrid-state tRNAs in translocating ribosomes.

Abstract:

Transfer RNAs (tRNAs) link the genetic code in the form of messenger RNA (mRNA) to protein sequence. Translocation of tRNAs through the ribosome from aminoacyl (A) site to peptidyl (P) site and from P site to exit site is catalyzed in eukaryotes by the translocase elongation factor 2 (EF-2) and in prokaryotes by its homolog EF-G. During tRNA movement one or more "hybrid" states (A/P) is occupied, but molecular details of them and of the translocation process are limited. Here we show by cryo-...

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Publication status:
Published

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Publisher copy:
10.1016/j.str.2009.12.007

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
Journal:
Structure (London, England : 1993)
Volume:
18
Issue:
2
Pages:
257-264
Publication date:
2010-02-01
DOI:
EISSN:
1878-4186
ISSN:
0969-2126
Source identifiers:
180383
Language:
English
Keywords:
Pubs id:
pubs:180383
UUID:
uuid:71ec40d4-1799-49c4-945d-bacc7414f465
Local pid:
pubs:180383
Deposit date:
2012-12-19

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