- Abstract:
-
Transfer RNAs (tRNAs) link the genetic code in the form of messenger RNA (mRNA) to protein sequence. Translocation of tRNAs through the ribosome from aminoacyl (A) site to peptidyl (P) site and from P site to exit site is catalyzed in eukaryotes by the translocase elongation factor 2 (EF-2) and in prokaryotes by its homolog EF-G. During tRNA movement one or more "hybrid" states (A/P) is occupied, but molecular details of them and of the translocation process are limited. Here we show by cryo-...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/j.str.2009.12.007
-
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- Journal:
- Structure (London, England : 1993)
- Volume:
- 18
- Issue:
- 2
- Pages:
- 257-264
- Publication date:
- 2010-02-05
- DOI:
- EISSN:
-
1878-4186
- ISSN:
-
0969-2126
- URN:
-
uuid:71ec40d4-1799-49c4-945d-bacc7414f465
- Source identifiers:
-
180383
- Local pid:
- pubs:180383
- Copyright date:
- 2010
Journal article
Direct observation of distinct A/P hybrid-state tRNAs in translocating ribosomes.
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