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Journal article

Direct observation of distinct A/P hybrid-state tRNAs in translocating ribosomes.

Abstract:

Transfer RNAs (tRNAs) link the genetic code in the form of messenger RNA (mRNA) to protein sequence. Translocation of tRNAs through the ribosome from aminoacyl (A) site to peptidyl (P) site and from P site to exit site is catalyzed in eukaryotes by the translocase elongation factor 2 (EF-2) and in prokaryotes by its homolog EF-G. During tRNA movement one or more "hybrid" states (A/P) is occupied, but molecular details of them and of the translocation process are limited. Here we show by cryo-...

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Publication status:
Published

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Publisher copy:
10.1016/j.str.2009.12.007

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
Role:
Author
Journal:
Structure (London, England : 1993)
Volume:
18
Issue:
2
Pages:
257-264
Publication date:
2010-02-05
DOI:
EISSN:
1878-4186
ISSN:
0969-2126
URN:
uuid:71ec40d4-1799-49c4-945d-bacc7414f465
Source identifiers:
180383
Local pid:
pubs:180383

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