Transfer RNAs (tRNAs) link the genetic code in the form of messenger RNA (mRNA) to protein sequence. Translocation of tRNAs through the ribosome from aminoacyl (A) site to peptidyl (P) site and from P site to exit site is catalyzed in eukaryotes by the translocase elongation factor 2 (EF-2) and in prokaryotes by its homolog EF-G. During tRNA movement one or more "hybrid" states (A/P) is occupied, but molecular details of them and of the translocation process are limited. Here we show by cryo-...Expand abstract
- Publication status:
- Publisher copy:
- Copyright date:
Direct observation of distinct A/P hybrid-state tRNAs in translocating ribosomes.
Views and Downloads
If you are the owner of this record, you can report an update to it here: Report update to this record