- Abstract:
-
Activating antibodies against the T-cell costimulator CD28 fall into two categories: those that require an additional stimulus, such as an anti-TCR antibody, to fully active a T cell are termed "conventional antibodies" (CAs), and those that induce such strong signalling that T cells become activated in the absence of TCR ligation are referred to as "superagonists" (SAs). It was proposed that SAs are particularly potent because they sterically exclude large phosphatases such as CD45 more ...
Expand abstract - Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
- English
- Subjects:
- Copyright date:
- 2016
Thesis
Imaging-based analysis of antibody superagonism
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