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Thesis

Imaging-based analysis of antibody superagonism

Abstract:

Activating antibodies against the T-cell costimulator CD28 fall into two categories: those that require an additional stimulus, such as an anti-TCR antibody, to fully active a T cell are termed "conventional antibodies" (CAs), and those that induce such strong signalling that T cells become activated in the absence of TCR ligation are referred to as "superagonists" (SAs). It was proposed that SAs are particularly potent because they sterically exclude large phosphatases such as CD45 more ...

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Department:
RDM Investigative Medicine
Role:
Author

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Department:
RDM Investigative Medicine
Role:
Supervisor
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Grant:
1238220
Funding agency for:
Meike Assmann
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Subjects:

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