Journal article icon

Journal article

CRM197-conjugated serogroup C meningococcal capsular polysaccharide, but not the native polysaccharide, induces persistent antigen-specific memory B cells.

Abstract:

Neisseria meningitidis is one of the leading causes of bacterial meningitis and septicemia in children. Vaccines containing the purified polysaccharide capsule from the organism, a T cell-independent antigen, have been available for decades but do not appear to provide protection in infancy or immunologic memory as measured by antibody responses. By contrast, T cell-dependent serogroup C protein-polysaccharide conjugate vaccines protect against serogroup C meningococcal disease from infancy o...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


More by this author
Institution:
University of Oxford
Department:
Oxford
Role:
Author
Expand authors...
Journal:
Blood
Volume:
108
Issue:
8
Pages:
2642-2647
Publication date:
2006-10-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:71be72bf-5f3e-418c-9e96-1d104b2359f8
Source identifiers:
119470
Local pid:
pubs:119470

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP