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A selective sweep driven by pyrimethamine treatment in southeast asian malaria parasites.

Abstract:

Malaria parasites (Plasmodium falciparum) provide an excellent system in which to study the genomic effects of strong selection in a recombining eukaryote because the rapid spread of resistance to multiple drugs during the last the past 50 years has been well documented, the full genome sequence and a microsatellite map are now available, and haplotype data can be easily generated. We examined microsatellite variation around the dihydrofolate reductase (dhfr) gene on chromosome 4 of P. falcip...

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Publication status:
Published

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Publisher copy:
10.1093/molbev/msg162

Authors


Williams, JT More by this author
Brockman, A More by this author
Paiphun, L More by this author
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Journal:
Molecular biology and evolution
Volume:
20
Issue:
9
Pages:
1526-1536
Publication date:
2003-09-05
DOI:
EISSN:
1537-1719
ISSN:
0737-4038
URN:
uuid:71bbb6e9-047c-4b88-bbdb-d1e5db5978f9
Source identifiers:
16233
Local pid:
pubs:16233

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