Journal article
GSK3β phosphorylates newly identified site in the proline-alanine-rich region of cardiac myosin-binding protein C and alters cross-bridge cycling kinetics in human: Short communication
- Abstract:
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Rationale: Cardiac myosin-binding protein C (cMyBP-C) regulates cross-bridge cycling kinetics and, thereby, fine-tunes the rate of cardiac muscle contraction and relaxation. Its effects on cardiac kinetics are modified by phosphorylation. Three phosphorylation sites (Ser275, Ser284, and Ser304) have been identified in vivo, all located in the cardiac-specific M-domain of cMyBP-C. However, recent work has shown that up to 4 phosphate groups are present in human cMyBP-C. Objective: To identify ...
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- Publisher copy:
- 10.1161/CIRCRESAHA.112.275602
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Bibliographic Details
- Journal:
- Circulation Research
- Volume:
- 112
- Issue:
- 4
- Pages:
- 633-639
- Publication date:
- 2013-02-15
- DOI:
- EISSN:
-
1524-4571
- ISSN:
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0009-7330
- Source identifiers:
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389225
Item Description
- Pubs id:
-
pubs:389225
- UUID:
-
uuid:71b72f0d-3b23-4a81-9800-964717c23ea6
- Local pid:
- pubs:389225
- Deposit date:
- 2013-11-17
Terms of use
- Copyright date:
- 2013
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