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GSK3β phosphorylates newly identified site in the proline-alanine-rich region of cardiac myosin-binding protein C and alters cross-bridge cycling kinetics in human: Short communication

Abstract:

Rationale: Cardiac myosin-binding protein C (cMyBP-C) regulates cross-bridge cycling kinetics and, thereby, fine-tunes the rate of cardiac muscle contraction and relaxation. Its effects on cardiac kinetics are modified by phosphorylation. Three phosphorylation sites (Ser275, Ser284, and Ser304) have been identified in vivo, all located in the cardiac-specific M-domain of cMyBP-C. However, recent work has shown that up to 4 phosphate groups are present in human cMyBP-C. Objective: To identify ...

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Journal:
Circulation Research
Volume:
112
Issue:
4
Pages:
633-639
Publication date:
2013-02-15
DOI:
EISSN:
1524-4571
ISSN:
0009-7330
URN:
uuid:71b72f0d-3b23-4a81-9800-964717c23ea6
Source identifiers:
389225
Local pid:
pubs:389225

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