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What you see is not what you get: implications of the brevity of antibody responses to malaria antigens and transmission heterogeneity in longitudinal studies of malaria immunity.

Abstract:

BACKGROUND: A major handicap in developing a malaria vaccine is the difficulty in pinpointing the immune responses that protect against malaria. The protective efficacy of natural or vaccine-induced immune responses against malaria is normally assessed by relating the level of the responses in an individual at the beginning of a follow-up period and the individual's experience of malaria infection or disease during the follow-up. This approach has identified a number of important responses a...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/1475-2875-8-242

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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Role:
Author
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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
Role:
Author
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Funding agency for:
Kinyanjui, SM
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Funding agency for:
Osier, FH
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Funding agency for:
Bull, PC
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Funding agency for:
Marsh, K
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Publisher:
BioMed Central Ltd. Publisher's website
Journal:
Malaria Journal Journal website
Volume:
8
Issue:
1
Pages:
Article: 242
Publication date:
2009-01-01
DOI:
EISSN:
1475-2875
ISSN:
1475-2875
URN:
uuid:71b53ea1-0601-4d24-a29f-1b71d7e3b2dd
Source identifiers:
41442
Local pid:
pubs:41442

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