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EGF receptor signalling protects smooth-cuticle cells from apoptosis during Drosophila ventral epidermis development.

Abstract:

Patterning of the Drosophila ventral epidermis is a tractable model for understanding the role of signalling pathways in development. Interplay between Wingless and EGFR signalling determines the segmentally repeated pattern of alternating denticle belts and smooth cuticle: spitz group genes, which encode factors that stimulate EGFR signalling, induce the denticle fate, while Wingless signalling antagonizes the effect of EGFR signalling, allowing cells to adopt the smooth-cuticle fate. Medial...

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Publication status:
Published

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Publisher copy:
10.1242/dev.01058

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Development (Cambridge, England)
Volume:
131
Issue:
8
Pages:
1835-1845
Publication date:
2004-04-05
DOI:
EISSN:
1477-9129
ISSN:
0950-1991
URN:
uuid:71a33354-8cec-428c-be2c-60d40f283b13
Source identifiers:
356070
Local pid:
pubs:356070

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