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Journal article

Exome-derived adiponectin-associated variants implicate obesity and lipid biology

Abstract:

Circulating levels of adiponectin, an adipocyte-secreted protein associated with cardiovascular and metabolic risk, are highly heritable. To gain insights into the biology that regulates adiponectin levels, we performed an exome array meta-analysis of 265,780 genetic variants in 67,739 individuals of European, Hispanic, African American, and East Asian ancestry. We identified 20 loci associated with adiponectin, including 11 that had been reported previously (p < 2 × 10-7). Comparison of e...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Subgroup:
Human Genetics Wt Centre
Role:
Author
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Publisher:
Elsevier Publisher's website
Journal:
American Journal of Human Genetics Journal website
Volume:
105
Issue:
1
Pages:
15-28
Publication date:
2019-08-06
Acceptance date:
2019-04-30
DOI:
EISSN:
1537-6605
ISSN:
0002-9297
Pmid:
31178129
Pubs id:
pubs:1011612
UUID:
uuid:719a9e4b-6e57-4ac5-a8fa-3184f8724c43
Source identifiers:
1011612
Local pid:
pubs:1011612

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