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Characterization of the rhesus macaque (Macaca mulatta) scrub typhus model: Susceptibility to intradermal challenge with the human pathogen Orientia tsutsugamushi Karp

Abstract:

Background

Scrub typhus is an important endemic disease in tropical Asia caused by Orientia tsutsugamushi for which no effective broadly protective vaccine is available. The successful evaluation of vaccine candidates requires well-characterized animal models and a better understanding of the immune response against O. tsutsugamushi. While many animal species have been used to study host immunity and vaccine responses in scrub typhus, only limited data exists in non-human primate...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pntd.0006305

Authors


Sunyakumthorn, P More by this author
Somponpun, SJ More by this author
Im-Erbsin, R More by this author
Anantatat, T More by this author
Jenjaroen, K More by this author
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Wellcome Trust More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Neglected Tropical Diseases Journal website
Volume:
12
Issue:
3
Pages:
e0006305
Publication date:
2018-03-09
Acceptance date:
2018-02-06
DOI:
EISSN:
1935-2735
ISSN:
1935-2727
Pubs id:
pubs:831051
URN:
uri:7195f6b3-77fc-411c-8fcf-6647460f7f25
UUID:
uuid:7195f6b3-77fc-411c-8fcf-6647460f7f25
Local pid:
pubs:831051
Language:
English
Keywords:

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