Journal article
Application of an Integrated GPCR SAR-Modelling Platform to Explain the Activation Selectivity of Human 5-HT2C over 5-HT2B
- Abstract:
-
Agonism of the 5-HT2C serotonin receptor has been associated with the treatment of a number of diseases including obesity, psychiatric disorders, sexual health and urology. However, the development of effective 5-HT2C agonists has been hampered by the difficulty in obtaining selectivity over the closely related 5-HT2B receptor, agonism of which is associated with irreversible cardiac valvulopathy. Understanding how to design selective agonists requires exploration of the structural features g...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Bibliographic Details
- Publisher:
- American Chemical Society
- Journal:
- ACS Chemical Biology More from this journal
- Volume:
- 11
- Issue:
- 5
- Pages:
- 1372–1382
- Publication date:
- 2016-02-22
- Acceptance date:
- 2016-02-22
- DOI:
- EISSN:
-
1554-8937
- ISSN:
-
1554-8929
Item Description
- Language:
-
English
- Keywords:
- Pubs id:
-
pubs:605950
- UUID:
-
uuid:718128d8-2433-468b-92e6-82fadfc5d67d
- Local pid:
-
info:fedora/pubs:605950
- Source identifiers:
-
605950
- Deposit date:
-
2016-03-14
Terms of use
- Copyright holder:
- American Chemical Society
- Copyright date:
- 2016
- Notes:
- Copyright © 2016 American Chemical Society. This is the accepted manuscript version of the article. The final version is available online from the American Chemical Society at: [10.1021/acschembio.5b01045]
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