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Extramitochondrial domain rich in carbonic anhydrase activity improves myocardial energetics.

Abstract:

CO2 is produced abundantly by cardiac mitochondria. Thus an efficient means for its venting is required to support metabolism. Carbonic anhydrase (CA) enzymes, expressed at various sites in ventricular myocytes, may affect mitochondrial CO2 clearance by catalyzing CO2 hydration (to H(+) and HCO3(-)), thereby changing the gradient for CO2 venting. Using fluorescent dyes to measure changes in pH arising from the intracellular hydration of extracellularly supplied CO2, overall CA activity in the...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.1213471110

Authors


Schroeder, MA More by this author
Hulikova, A More by this author
Supuran, CT More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics, BHF Centre of Research Excellence
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
110
Issue:
10
Pages:
E958-E967
Publication date:
2013-03-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:71747367-45d9-482f-ac27-d26c04a0f125
Source identifiers:
387139
Local pid:
pubs:387139

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