Autoantibodies to the islet cell antigen SOX-13 are associated with duration but not type of diabetes.

Journal article

AIMS: The autoantigen SOX-13 of the SRY-related high mobility group box is a low-frequency reactant in sera from patients with Type 1 diabetes. We further investigated the potential diagnostic role of anti-SOX-13, and in particular its ability to distinguish Type 1 from Type 2 diabetes, in two large, well-characterized cohorts. METHODS: SOX-13 autoantibody status was ascertained using a radioimmunoprecipitation assay in (i) a random sample of 546 participants in an Australian community-based ...

Expand abstract

Authors: Davis, T; Mehta, Z; Mackay, I; Cull, C; Bruce, D

• Publication status: Published
• Journal: Diabetic medicine : a journal of the British Diabetic Association
• Volume: 20
• Issue: 3
• Pages: 198-204
• Publication date: 2003-03-01
• DOI: 10.1046/j.1464-5491.2003.00897.x
• EISSN: 1464-5491
• ISSN: 0742-3071
• Language: English
• Keywords: Body Mass Index; Male; Aged; Autoantibodies; Adult; Protein Tyrosine Phosphatases; Autoantigens; Diabetes Mellitus, Type 1; Radioimmunoprecipitation Assay; Middle Aged; Cohort Studies; Membrane Proteins; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Prospective Studies; Receptor-Like Protein Tyrosine Phosphatases, Class 8; Female; Humans; Diabetes Mellitus, Type 2