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MacroH2A1.1 regulates mitochondrial respiration by limiting nuclear NAD+ consumption.

Abstract:

Histone variants are structural components of eukaryotic chromatin that can replace replication-coupled histones in the nucleosome. The histone variant macroH2A1.1 contains a macrodomain capable of binding NAD+-derived metabolites. Here we report that macroH2A1.1 is rapidly induced during myogenic differentiation through a switch in alternative splicing, and that myotubes that lack macroH2A1.1 have a defect in mitochondrial respiratory capacity. We found that the metabolite-binding macrodomai...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/nsmb.3481

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Spanish Ministry of Economy and Competitiveness More from this funder
French Muscular Dystrophy Association More from this funder
Horizon 2020 More from this funder
Minerva Foundation More from this funder
German Center for Diabetes Research More from this funder
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Structural & Molecular Biology Journal website
Publication date:
2017-10-05
Acceptance date:
2017-09-13
DOI:
EISSN:
1545-9985
ISSN:
1545-9993
Pubs id:
pubs:737098
URN:
uri:71710a27-1c31-4e05-89ec-e82a18e9465e
UUID:
uuid:71710a27-1c31-4e05-89ec-e82a18e9465e
Local pid:
pubs:737098
Language:
English
Keywords:

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