Journal article
MacroH2A1.1 regulates mitochondrial respiration by limiting nuclear NAD+ consumption.
- Abstract:
-
Histone variants are structural components of eukaryotic chromatin that can replace replication-coupled histones in the nucleosome. The histone variant macroH2A1.1 contains a macrodomain capable of binding NAD+-derived metabolites. Here we report that macroH2A1.1 is rapidly induced during myogenic differentiation through a switch in alternative splicing, and that myotubes that lack macroH2A1.1 have a defect in mitochondrial respiratory capacity. We found that the metabolite-binding macrodomai...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.1038/nsmb.3481
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Authors
Funding
Spanish Ministry of Economy and Competitiveness
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French Muscular Dystrophy Association
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Horizon 2020
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Minerva Foundation
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German Center for Diabetes Research
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Bibliographic Details
- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Nature Structural & Molecular Biology Journal website
- Publication date:
- 2017-10-01
- Acceptance date:
- 2017-09-13
- DOI:
- EISSN:
-
1545-9985
- ISSN:
-
1545-9993
- Pmid:
-
28991266
- Source identifiers:
-
737098
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:737098
- UUID:
-
uuid:71710a27-1c31-4e05-89ec-e82a18e9465e
- Local pid:
- pubs:737098
- Deposit date:
- 2017-11-15
Terms of use
- Copyright date:
- 2017
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