- Abstract:
-
Histone variants are structural components of eukaryotic chromatin that can replace replication-coupled histones in the nucleosome. The histone variant macroH2A1.1 contains a macrodomain capable of binding NAD+-derived metabolites. Here we report that macroH2A1.1 is rapidly induced during myogenic differentiation through a switch in alternative splicing, and that myotubes that lack macroH2A1.1 have a defect in mitochondrial respiratory capacity. We found that the metabolite-binding macrodomai...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Publisher copy:
- 10.1038/nsmb.3481
-
Version unsuitable
-
We have not obtained a suitable full-text for a given research output. See this page for more information.
-
Recently completed
-
Sometimes content is held in ORA but is unavailable for a fixed period of time to comply with the policies and wishes of rights holders.
-
Permissions
-
All content made available in ORA should comply with relevant rights, such as copyright. See this page for more information.
-
Clearance
-
Some thesis volumes scanned as part of the digitisation scheme funded by Dr Leonard Polonsky are currently unavailable due to sensitive material or uncleared third-party copyright content. We are attempting to contact authors whose theses are affected.
- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Nature Structural & Molecular Biology Journal website
- Publication date:
- 2017-10-05
- Acceptance date:
- 2017-09-13
- DOI:
- EISSN:
-
1545-9985
- ISSN:
-
1545-9993
- Pubs id:
-
pubs:737098
- URN:
-
uri:71710a27-1c31-4e05-89ec-e82a18e9465e
- UUID:
-
uuid:71710a27-1c31-4e05-89ec-e82a18e9465e
- Local pid:
- pubs:737098
- Language:
- English
- Keywords:
- Copyright date:
- 2017
Journal article
MacroH2A1.1 regulates mitochondrial respiration by limiting nuclear NAD+ consumption.
Actions
Access Document
Why is the content I wish to access not available via ORA?
Bibliographic data (the information relating to research outputs) and full-text items (e.g. articles, theses, reports, etc.) arrive in ORA from several different sources. Unfortunately we are not able to make available the full-text for every research output.
Please contact the ORA team (
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
Content may be unavailable for the following four reasons
Alternative access to the full-text
You may be able to access the full-text directly from the publisher's website using the 'Publisher Copy' link in the 'Links & Downloads' box from a research output's ORA record page. This method may require an institutional or individual subscription to the journal/resource.
Authors
Funding
Spanish Ministry of Economy and Competitiveness
More from this funder
French Muscular Dystrophy Association
More from this funder
Horizon 2020
More from this funder
Minerva Foundation
More from this funder
German Center for Diabetes Research
More from this funder
Expand funders...
Bibliographic Details
Item Description
Terms of use
Metrics
Altmetrics
Dimensions
If you are the owner of this record, you can report an update to it here: Report update to this record