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The ClC-5 knockout mouse model of Dent's disease has renal hypercalciuria and increased bone turnover.

Abstract:

Dent's disease is a nephrolithiasis disorder associated with hypercalciuria and low molecular weight proteinuria that is caused by mutations in the voltage-gated chloride channel ClC-5. Because the exact cause of hypercalciuria in this disease is unknown and could come from a renal, intestinal, or bone origin, we have investigated overall calcium handling in the ClC-5 knockout mouse (ClC-5 KO). On a high calcium diet, ClC-5 KO mice had elevated serum 1alpha,25-dihydroxyvitamin D3 (1alpha,25D3...

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Publication status:
Published

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Publisher copy:
10.1359/jbmr.2003.18.4.615

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Journal:
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Volume:
18
Issue:
4
Pages:
615-623
Publication date:
2003-04-05
DOI:
EISSN:
1523-4681
ISSN:
0884-0431
URN:
uuid:71574c96-ca2b-4d07-84a9-93d6da0e515f
Source identifiers:
15565
Local pid:
pubs:15565

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