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A genome-wide copy number association study of osteoporotic fractures points to the 6p25.1 locus.

Abstract:

BACKGROUND: Osteoporosis is a systemic skeletal disease characterised by reduced bone mineral density and increased susceptibility to fracture; these traits are highly heritable. Both common and rare copy number variants (CNVs) potentially affect the function of genes and may influence disease risk. AIM: To identify CNVs associated with osteoporotic bone fracture risk. METHOD: We performed a genome-wide CNV association study in 5178 individuals from a prospective cohort in the Netherlands, in...

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Publication status:
Published

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Authors


Styrkarsdottir, U More by this author
Eussen, BH More by this author
de Klein, A More by this author
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Journal:
Journal of medical genetics
Volume:
51
Issue:
2
Pages:
122-131
Publication date:
2014-02-05
DOI:
EISSN:
1468-6244
ISSN:
0022-2593
URN:
uuid:71553239-7851-4119-b4b1-0e108435bc39
Source identifiers:
450869
Local pid:
pubs:450869

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