- Abstract:
-
Interindividual variation in mean leukocyte telomere length (LTL) is associated with cancer and several age-associated diseases. We report here a genome-wide meta-analysis of 37,684 individuals with replication of selected variants in an additional 10,739 individuals. We identified seven loci, including five new loci, associated with mean LTL (P < 5 × 10(-8)). Five of the loci contain candidate genes (TERC, TERT, NAF1, OBFC1 and RTEL1) that are known to be involved in telomere biology. Lea...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1038/ng.2528
-
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- Journal:
- Nature genetics
- Volume:
- 45
- Issue:
- 4
- Pages:
- 422-427e2
- Publication date:
- 2013-04-05
- DOI:
- EISSN:
-
1546-1718
- ISSN:
-
1061-4036
- URN:
-
uuid:714fafd9-a9be-40b3-8852-9264000b01c2
- Source identifiers:
-
395069
- Local pid:
- pubs:395069
- Copyright date:
- 2013
Journal article
Identification of seven loci affecting mean telomere length and their association with disease.
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