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Identification of seven loci affecting mean telomere length and their association with disease.

Abstract:

Interindividual variation in mean leukocyte telomere length (LTL) is associated with cancer and several age-associated diseases. We report here a genome-wide meta-analysis of 37,684 individuals with replication of selected variants in an additional 10,739 individuals. We identified seven loci, including five new loci, associated with mean LTL (P < 5 × 10(-8)). Five of the loci contain candidate genes (TERC, TERT, NAF1, OBFC1 and RTEL1) that are known to be involved in telomere biology. Lea...

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Publication status:
Published

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Publisher copy:
10.1038/ng.2528

Authors


Nelson, CP More by this author
Albrecht, E More by this author
Mangino, M More by this author
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Journal:
Nature genetics
Volume:
45
Issue:
4
Pages:
422-427e2
Publication date:
2013-04-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:714fafd9-a9be-40b3-8852-9264000b01c2
Source identifiers:
395069
Local pid:
pubs:395069

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