Journal article
Dependence of T cell antigen recognition on the dimensions of an accessory receptor-ligand complex.
- Abstract:
-
The T cell antigen receptor (TCR) and its ligand peptide-major histocompatibility complex (MHC) are small (approximately 7 nm) compared with other abundant cell surface molecules such as integrins, CD43, and CD45 (23-50 nm). We have proposed that molecules at the T cell/antigen-presenting cell (APC) interface segregate according to size, with small "accessory" molecules (e.g., CD2, CD4, CD8, CD28, and CD154) contributing to the formation of a close-contact zone, within which the TCR engages p...
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- Publication status:
- Published
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- Publisher copy:
- 10.1084/jem.190.1.31
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Authors
Bibliographic Details
- Journal:
- The Journal of experimental medicine
- Volume:
- 190
- Issue:
- 1
- Pages:
- 31-41
- Publication date:
- 1999-07-05
- DOI:
- EISSN:
-
1540-9538
- ISSN:
-
0022-1007
- URN:
-
uuid:7146d3dd-49ed-4988-a79d-c4ed4ebb029a
- Source identifiers:
-
27779
- Local pid:
- pubs:27779
Item Description
Terms of use
- Copyright date:
- 1999
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