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Dependence of T cell antigen recognition on the dimensions of an accessory receptor-ligand complex.

Abstract:

The T cell antigen receptor (TCR) and its ligand peptide-major histocompatibility complex (MHC) are small (approximately 7 nm) compared with other abundant cell surface molecules such as integrins, CD43, and CD45 (23-50 nm). We have proposed that molecules at the T cell/antigen-presenting cell (APC) interface segregate according to size, with small "accessory" molecules (e.g., CD2, CD4, CD8, CD28, and CD154) contributing to the formation of a close-contact zone, within which the TCR engages p...

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Publication status:
Published

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Publisher copy:
10.1084/jem.190.1.31

Authors


Cambiaggi, A More by this author
Davies, EA More by this author
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Journal:
The Journal of experimental medicine
Volume:
190
Issue:
1
Pages:
31-41
Publication date:
1999-07-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:7146d3dd-49ed-4988-a79d-c4ed4ebb029a
Source identifiers:
27779
Local pid:
pubs:27779

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