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i-Patch: interprotein contact prediction using local network information.

Abstract:

Biological processes are commonly controlled by precise protein-protein interactions. These connections rely on specific amino acids at the binding interfaces. Here we predict the binding residues of such interprotein complexes. We have developed a suite of methods, i-Patch, which predict the interprotein contact sites by considering the two proteins as a network, with residues as nodes and contacts as edges. i-Patch starts with two proteins, A and B, which are assumed to interact, but for wh...

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Publication status:
Published

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Publisher copy:
10.1002/prot.22792

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Institution:
University of Oxford
Department:
Oxford, MPLS, Statistics
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Statistics
Role:
Author
Journal:
Proteins
Volume:
78
Issue:
13
Pages:
2781-2797
Publication date:
2010-10-05
DOI:
EISSN:
1097-0134
ISSN:
0887-3585
URN:
uuid:71361f9e-757e-47e9-8710-f02a2975fca1
Source identifiers:
90970
Local pid:
pubs:90970

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