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The role of CD1a-restricted T cells and phospholipase in allergic disease

Abstract:

The skin is an important barrier against a range of different environmental challenges. The skin associated immune system is able to detect breaks in the barrier to initiate a protective immune response. Langerhans cells express a high density of CD1a, which presents lipid antigens to T-cells. However little is known about CD1a-restricted lipid antigens and the role of CD1a-restricted T-cells in inflammatory skin disease.

In order to investigate the role of T-cells that react to CD1...

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Department:
University of Oxford, MSD, RDM
Role:
Author

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Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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