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Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials.

Abstract:

BACKGROUND: High-dose aspirin (≥500 mg daily) reduces long-term incidence of colorectal cancer, but adverse effects might limit its potential for long-term prevention. The long-term effectiveness of lower doses (75-300 mg daily) is unknown. We assessed the effects of aspirin on incidence and mortality due to colorectal cancer in relation to dose, duration of treatment, and site of tumour. METHODS: We followed up four randomised trials of aspirin versus control in primary (Thrombosis Preventio...

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Publication status:
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience, Biomedical Research Centre
Norrving, B More by this author
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Journal:
Lancet
Volume:
376
Issue:
9754
Pages:
1741-1750
Publication date:
2010-11-05
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
URN:
uuid:7130b148-99eb-4ec8-8da7-eefd63c81ee5
Source identifiers:
119096
Local pid:
pubs:119096

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