- Abstract:
-
High-risk mutations in several genes predispose to both colorectal cancer (CRC) and endometrial cancer (EC). We therefore hypothesised that some lower-risk genetic variants might also predispose to both CRC and EC. Using CRC and EC genome-wide association series, totalling 13,265 cancer cases and 40,245 controls, we found that the protective allele [G] at one previously-identified CRC polymorphism, rs2736100 near TERT, was associated with EC risk (odds ratio (OR) = 1.08, P = 0.000167); this p...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
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(pdf, 861.9kb)
-
- Publisher copy:
- 10.1038/srep17369
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- Publisher:
- Nature Publisher's website
- Journal:
- Scientific Reports Journal website
- Volume:
- 5
- Pages:
- 17369
- Publication date:
- 2015-01-05
- DOI:
- EISSN:
-
2045-2322
- ISSN:
-
2045-2322
- URN:
-
uuid:711fe7ea-79e6-4c61-a5c6-97da479ee837
- Source identifiers:
-
580702
- Local pid:
- pubs:580702
- Language:
- English
- Copyright holder:
- Cheng et al
- Copyright date:
- 2015
- Notes:
- This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Journal article
Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1.
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The V Foundation for Cancer Research
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Cancer Research UK
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Tenovus
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The Kidani Trust
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