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Focal destructive cholangiopathy associated with amoxycillin/clavulanic acid (Augmentin).

Abstract:

Amoxycillin/clavulanic acid (Augmentin) has been widely used as a broad spectrum antibiotic since its introduction in 1981, since which time a number of reports of adverse hepatic reaction to the drug combination have been published. This paper describes five patients presenting with cholestatic illness within 8 weeks of a course of amoxycillin/clavulanic acid. The clinical picture indicated a direct link between the illness and the drug combination. Hepatic histology revealed a distinctive f...

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Journal:
Journal of hepatology
Volume:
23
Issue:
3
Pages:
278-282
Publication date:
1995-09-05
DOI:
EISSN:
1600-0641
ISSN:
0168-8278
URN:
uuid:711c5291-2809-4f3c-83c4-be76f8f0d286
Source identifiers:
184658
Local pid:
pubs:184658

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