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Journal article

Farnesyltransferase inhibitors: an overview of the results of preclinical and clinical investigations.

Abstract:

This article presents an overview of preclinical studies and clinical trials of a number of independently derived farnesyltransferase inhibitors (FTIs). Potential targets and biological modes of action of FTIs are discussed, and the results of clinical trials are summarized. The significant efficacy of FTIs as single or combined agents in preclinical studies stands in contrast with only moderate effects in clinical Phase II-III trials. These results reveal a substantial gap in the understandi...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
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Journal:
Cancer research
Volume:
63
Issue:
18
Pages:
5656-5668
Publication date:
2003-09-05
EISSN:
1538-7445
ISSN:
0008-5472
URN:
uuid:710ad328-09fd-4d9a-aab4-b8c4f5711568
Source identifiers:
118196
Local pid:
pubs:118196

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