Journal article
Farnesyltransferase inhibitors: an overview of the results of preclinical and clinical investigations.
- Abstract:
-
This article presents an overview of preclinical studies and clinical trials of a number of independently derived farnesyltransferase inhibitors (FTIs). Potential targets and biological modes of action of FTIs are discussed, and the results of clinical trials are summarized. The significant efficacy of FTIs as single or combined agents in preclinical studies stands in contrast with only moderate effects in clinical Phase II-III trials. These results reveal a substantial gap in the understandi...
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- Publication status:
- Published
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Bibliographic Details
- Journal:
- Cancer research
- Volume:
- 63
- Issue:
- 18
- Pages:
- 5656-5668
- Publication date:
- 2003-09-01
- EISSN:
-
1538-7445
- ISSN:
-
0008-5472
- Source identifiers:
-
118196
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:118196
- UUID:
-
uuid:710ad328-09fd-4d9a-aab4-b8c4f5711568
- Local pid:
- pubs:118196
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2003
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