Farnesyltransferase inhibitors: an overview of the results of preclinical and clinical investigations.

Brunner, TB; Hahn, SM; Gupta, AK; Muschel, RJ; Mckenna, WG; Bernhard, EJ

Abstract:

This article presents an overview of preclinical studies and clinical trials of a number of independently derived farnesyltransferase inhibitors (FTIs). Potential targets and biological modes of action of FTIs are discussed, and the results of clinical trials are summarized. The significant efficacy of FTIs as single or combined agents in preclinical studies stands in contrast with only moderate effects in clinical Phase II-III trials. These results reveal a substantial gap in the understandi...

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APA Style

Brunner, T. B., Hahn, S. M., Gupta, A. K., Muschel, R. J., Mckenna, W. G., & Bernhard, E. J. (2003). Farnesyltransferase inhibitors: an overview of the results of preclinical and clinical investigations. Cancer Research, 63(18), 5656–5668.

MLA Style

Brunner, T. B., et al. “Farnesyltransferase Inhibitors: an Overview of the Results of Preclinical and Clinical Investigations.” Cancer Research, vol. 63, no. 18, 2003, pp. 5656–68.

Chicago Style

Brunner, TB, SM Hahn, AK Gupta, RJ Muschel, WG Mckenna, and EJ Bernhard. 2003. “Farnesyltransferase Inhibitors: an Overview of the Results of Preclinical and Clinical Investigations.” Cancer Research 63 (18): 5656–68.
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