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Journal article

Early diagnosis of brain metastases using a biofluids-metabolomics approach in mice

Abstract:

Over 20% of cancer patients will develop brain metastases. Prognosis is currently extremely poor, largely owing to late-stage diagnosis. We hypothesized that biofluid metabolomics could detect tumours at the micrometastatic stage, prior to the current clinical gold-standard of blood-brain barrier breakdown.

Metastatic mammary carcinoma cells (4T1-GFP) were injected into BALB/c mice via intracerebral, intracardiac or intravenous routes to induce differing cerebral and systemic tumour...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.7150/thno.16538

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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
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Funding agency for:
Dickens, A
Grant:
Capacity Building Studentship
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Funding agency for:
Sibson, N
Grant:
C5255/A15935
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Grant:
Capacity Building Studentship
Publisher:
Ivyspring International Publisher Publisher's website
Journal:
Theranostics Journal website
Volume:
6
Issue:
12
Pages:
2161-2169
Publication date:
2016-09-12
Acceptance date:
2016-06-27
DOI:
EISSN:
1838-7640
ISSN:
1838-7640
Source identifiers:
632240
Keywords:
Pubs id:
pubs:632240
UUID:
uuid:70fd5f3c-2444-4298-a0f5-29676169a4e2
Local pid:
pubs:632240
Deposit date:
2016-07-06

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