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Journal article

Early diagnosis of brain metastases using a biofluids-metabolomics approach in mice

Abstract:

Over 20% of cancer patients will develop brain metastases. Prognosis is currently extremely poor, largely owing to late-stage diagnosis. We hypothesized that biofluid metabolomics could detect tumours at the micrometastatic stage, prior to the current clinical gold-standard of blood-brain barrier breakdown.

Metastatic mammary carcinoma cells (4T1-GFP) were injected into BALB/c mice via intracerebral, intracardiac or intravenous routes to induce differing cerebral and systemic tumour...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.7150/thno.16538

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
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Funding agency for:
Dickens, AM
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Funding agency for:
Sibson, N
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Grant:
Capacity Building Studentship
Publisher:
Ivyspring International Publisher Publisher's website
Journal:
Theranostics Journal website
Volume:
6
Issue:
12
Pages:
2161-2169
Publication date:
2016-09-12
Acceptance date:
2016-06-27
DOI:
EISSN:
1838-7640
ISSN:
1838-7640
URN:
uuid:70fd5f3c-2444-4298-a0f5-29676169a4e2
Source identifiers:
632240
Local pid:
pubs:632240
Paper number:
12

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