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An Arabidopsis Rhomboid homolog is an intramembrane protease in plants.

Abstract:

Regulated intramembrane proteolysis (RIP) is a fundamental mechanism for controlling a wide range of cellular functions. The Drosophila protein Rhomboid-1 (Rho-1) is an intramembrane serine protease that cleaves epidermal growth factor receptor (EGFR) ligands to release active growth factors. Despite differences in the primary structure of Rhomboid proteins, the proteolytic activity and substrate specificity of these enzymes has been conserved in diverse organisms. Here, we show that an Arabi...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
FEBS letters
Volume:
579
Issue:
25
Pages:
5723-5728
Publication date:
2005-10-05
DOI:
EISSN:
1873-3468
ISSN:
0014-5793
URN:
uuid:70fc45db-8b0c-41a9-b826-4a48443c0b3c
Source identifiers:
356067
Local pid:
pubs:356067

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