Journal article
Downregulation of ASPP1 in gestational trophoblastic disease: correlation with hypermethylation, apoptotic activity and clinical outcome.
- Abstract:
-
Gestational trophoblastic disease encompasses a spectrum of trophoblastic lesions including true neoplasms such as choriocarcinomas and the potentially malignant hydatidiform moles, which may develop persistent disease requiring chemotherapy. ASPP1, a member of apoptosis-stimulating proteins of p53 (ASPPs), is a proapoptotic protein that can stimulate apoptosis through its interaction with p53. We evaluated the promoter methylation and expression profiles of ASPP1 in different trophoblastic t...
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- Publication status:
- Published
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- Publisher copy:
- 10.1038/modpathol.2010.216
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Bibliographic Details
- Journal:
- Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
- Volume:
- 24
- Issue:
- 4
- Pages:
- 522-532
- Publication date:
- 2011-04-05
- DOI:
- EISSN:
-
1530-0285
- ISSN:
-
0893-3952
- URN:
-
uuid:70fade8b-b533-45f1-9d50-4b10291249bb
- Source identifiers:
-
97338
- Local pid:
- pubs:97338
Item Description
- Language:
- English
- Keywords:
Terms of use
- Copyright date:
- 2011
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