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A study based on whole-genome sequencing yields a rare variant at 8q24 associated with prostate cancer.

Abstract:

In Western countries, prostate cancer is the most prevalent cancer of men and one of the leading causes of cancer-related death in men. Several genome-wide association studies have yielded numerous common variants conferring risk of prostate cancer. Here, we analyzed 32.5 million variants discovered by whole-genome sequencing 1,795 Icelanders. We identified a new low-frequency variant at 8q24 associated with prostate cancer in European populations, rs188140481[A] (odds ratio (OR) = 2.90; P(co...

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Publication status:
Published

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Publisher copy:
10.1038/ng.2437

Authors


Gudmundsson, J More by this author
Gudbjartsson, DF More by this author
Agnarsson, BA More by this author
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Journal:
Nature genetics
Volume:
44
Issue:
12
Pages:
1326-1329
Publication date:
2012-12-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:70f9fdf7-8d0d-4ac3-bf01-dac5d4448aa5
Source identifiers:
358355
Local pid:
pubs:358355

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