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The hypoxia-inducible genes VEGF and CA9 are differentially regulated in superficial vs invasive bladder cancer.

Abstract:

Regulation by hypoxia may underlie the expression of vascular endothelial growth factor in bladder cancer. We have compared the distribution of vascular endothelial growth factor mRNA with a hypoxia marker, carbonic anhydrase 9 (CA IX). vascular endothelial growth factor mRNA was analysed by in situ hybridisation and CA IX by immunochemistry in 22 cases of bladder cancer. The relationship of microvessels to the distribution of CA IX was determined. In a separate series of 49 superficial tumou...

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Publication status:
Published

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Publisher copy:
10.1038/sj.bjc.6600215

Authors


Turner, KJ More by this author
Wykoff, CC More by this author
Watson, PH More by this author
Poulsom, R More by this author
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Journal:
British journal of cancer
Volume:
86
Issue:
8
Pages:
1276-1282
Publication date:
2002-04-05
DOI:
EISSN:
1532-1827
ISSN:
0007-0920
URN:
uuid:70f884c4-4b19-42fc-ba52-985418cea832
Source identifiers:
7245
Local pid:
pubs:7245

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