The hypoxia-inducible genes VEGF and CA9 are differentially regulated in superficial vs invasive bladder cancer.

Journal article

Regulation by hypoxia may underlie the expression of vascular endothelial growth factor in bladder cancer. We have compared the distribution of vascular endothelial growth factor mRNA with a hypoxia marker, carbonic anhydrase 9 (CA IX). vascular endothelial growth factor mRNA was analysed by in situ hybridisation and CA IX by immunochemistry in 22 cases of bladder cancer. The relationship of microvessels to the distribution of CA IX was determined. In a separate series of 49 superficial tumou...

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Authors: Turner, K; Crew, J; Wykoff, C; Watson, P; Poulsom, R

• Publication status: Published
• Journal: British journal of cancer
• Volume: 86
• Issue: 8
• Pages: 1276-1282
• Publication date: 2002-04-01
• DOI: 10.1038/sj.bjc.6600215
• EISSN: 1532-1827
• ISSN: 0007-0920
• Language: English
• Keywords: Vascular Endothelial Growth Factor A; Recurrence; Gene Expression Regulation, Neoplastic; Immunohistochemistry; Vascular Endothelial Growth Factors; Neoplasm Invasiveness; Tumor Cells, Cultured; Prognosis; Humans; Lymphokines; Tumor Markers, Biological; Antigens, Neoplasm; RNA, Messenger; Endothelial Growth Factors; Blotting, Western; Carbonic Anhydrases; In Situ Hybridization; Urinary Bladder Neoplasms; Neoplasm Proteins