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Histone deacetylase inhibitors increase virus gene expression but decrease CD8+ cell antiviral function in HTLV-1 infection.

Abstract:

The dynamics of human T-lymphotropic virus type-1 (HTLV-1) provirus expression in vivo are unknown. There is much evidence to suggest that HTLV-1 gene expression is restricted: this restricted gene expression may contribute to HTLV-1 persistence by limiting the ability of the HTLV-1-specific CD8(+) cell immune response to clear infected cells. In this study, we tested the hypothesis that derepression of HTLV-1 gene expression would allow an increase in CD8(+) cell-mediated lysis of HTLV-1-inf...

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Publication status:
Published

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Authors


Mosley, AJ More by this author
Meekings, KN More by this author
McCarthy, C More by this author
Shepherd, D More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine, Biomedical Research Centre
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Journal:
Blood
Volume:
108
Issue:
12
Pages:
3801-3807
Publication date:
2006-12-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:70f534c3-f1f3-46e2-9fa1-048aec60d00b
Source identifiers:
33579
Local pid:
pubs:33579

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