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Genetic pathways of colorectal carcinogenesis rarely involve the PTEN and LKB1 genes outside the inherited hamartoma syndromes.

Abstract:

Germline mutations of the PTEN/MMAC1/TEP and LKB1 genes cause hamartomas to develop in the gastrointestinal tracts of patients with Cowden syndrome and Peutz-Jeghers syndrome, respectively. PTEN mutations may also be responsible for some cases of juvenile polyposis. Histologically, hamartomas appear benign, but there is good evidence that in these syndromes, the hamartomas can progress to colorectal carcinoma. It remains unknown whether or not cancers that develop from hamartomas acquire a sp...

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Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Role:
Author
Journal:
The American journal of pathology
Volume:
153
Issue:
2
Pages:
363-366
Publication date:
1998-08-05
DOI:
EISSN:
1525-2191
ISSN:
0002-9440
URN:
uuid:70ef421f-7f69-4f7c-bbc3-8642fa81f46d
Source identifiers:
36220
Local pid:
pubs:36220

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