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Journal article

Alpha-MSH regulates intergenic splicing of MC1R and TUBB3 in human melanocytes.

Abstract:

Alternative splicing enables higher eukaryotes to increase their repertoire of proteins derived from a restricted number of genes. However, the possibility that functional diversity may also be augmented by splicing between adjacent genes has been largely neglected. Here, we show that the human melanocortin 1 receptor (MC1R) gene, a critical component of the facultative skin pigmentation system, has a highly complex and inefficient poly(A) site which is instrumental in allowing intergenic spl...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/nar/gkq1125

Authors


Dalziel, M More by this author
Kolesnichenko, M More by this author
das Neves, RP More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Ludwig Institute
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Publisher:
Oxford University Press Publisher's website
Journal:
Nucleic acids research Journal website
Volume:
39
Issue:
6
Pages:
2378-2392
Publication date:
2011-03-05
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:70e57943-f85b-4e8d-a9a5-3d749722213a
Source identifiers:
94645
Local pid:
pubs:94645

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