- Abstract:
-
Alternative splicing enables higher eukaryotes to increase their repertoire of proteins derived from a restricted number of genes. However, the possibility that functional diversity may also be augmented by splicing between adjacent genes has been largely neglected. Here, we show that the human melanocortin 1 receptor (MC1R) gene, a critical component of the facultative skin pigmentation system, has a highly complex and inefficient poly(A) site which is instrumental in allowing intergenic spl...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 3.7mb)
-
- Publisher copy:
- 10.1093/nar/gkq1125
-
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- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Nucleic acids research Journal website
- Volume:
- 39
- Issue:
- 6
- Pages:
- 2378-2392
- Publication date:
- 2011-03-05
- DOI:
- EISSN:
-
1362-4962
- ISSN:
-
0305-1048
- URN:
-
uuid:70e57943-f85b-4e8d-a9a5-3d749722213a
- Source identifiers:
-
94645
- Local pid:
- pubs:94645
- Copyright holder:
- Dalziel et al.
- Copyright date:
- 2011
- Notes:
- Copyright © 2010 Dalziel et al. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Journal article
Alpha-MSH regulates intergenic splicing of MC1R and TUBB3 in human melanocytes.
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