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Successful therapy of collagen-induced arthritis with TNF receptor-IgG fusion protein and combination with anti-CD4.

Abstract:

We have previously shown that anti-tumour necrosis factor (TNF) monoclonal antibody (mAb) ameliorates established collagen-induced arthritis and that the efficacy of this form of treatment can be enhanced by concurrent anti-CD4 treatment. Here we assess the efficacy of a human p55 TNF receptor-IgG fusion protein (p55-sf2), given alone or with anti-CD4 mAb. TNF receptor-IgG fusion protein (100 micrograms) suppressed paw swelling and limb recruitment in established arthritis and reduced the inc...

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Publication status:
Published

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Authors


Williams, RO More by this author
Ghrayeb, J More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Journal:
Immunology
Volume:
84
Issue:
3
Pages:
433-439
Publication date:
1995-03-05
EISSN:
1365-2567
ISSN:
0019-2805
URN:
uuid:70d6d721-d26c-456f-b19d-c0b07d20c721
Source identifiers:
481646
Local pid:
pubs:481646

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