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Thesis

Phosphorylation of the human topoisomerase II protein

Abstract:

DNA topoisomerase II is an essential enzyme in eukaryotes and is required for many aspects of DNA metabolism including DNA replication, recombination, chromosome segregation and chromosome condensation. It is also a major component of the nuclear scaffold. Topoisomerase II from lower eukaryotes has been shown to be phosphorylated in vivo and this phosphorylation leads to a modulation of activity. However, unlike these lower eukaryotes, human topoisomerase II exists as two closely...

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Institution:
University of Oxford
Department:
Medical Sciences Division

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Role:
Supervisor
Role:
Supervisor
Publication date:
1992
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Barcode:
603851196
URN:
uuid:70d2dbb9-d3fe-43ed-8206-44a95202eeff
Local pid:
td:603851196
Language:
English
Subjects:

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