Journal article
Genetic dissection of the α-globin super-enhancer in vivo
- Abstract:
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Many genes determining cell identity are regulated by clusters of Mediator-bound enhancer elements collectively referred to as super-enhancers. These super-enhancers have been proposed to manifest higher-order properties important in development and disease. Here we report a comprehensive functional dissection of one of the strongest putative super-enhancers in erythroid cells. By generating a series of mouse models, deleting each of the five regulatory elements of the α-globin super-enhancer...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Accepted manuscript, pdf, 237.4KB, Terms of use)
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- Publisher copy:
- 10.1038/ng.3605
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Funding
Bibliographic Details
- Publisher:
- Nature Publishing Group
- Journal:
- Nature Genetics More from this journal
- Volume:
- 48
- Issue:
- 8
- Pages:
- 895-903
- Publication date:
- 2016-08-01
- Acceptance date:
- 2016-06-01
- DOI:
- EISSN:
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1546-1718
- ISSN:
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1061-4036
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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pubs:633464
- UUID:
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uuid:70d2690b-fcde-48ee-9be5-982faa0ab220
- Local pid:
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pubs:633464
- Source identifiers:
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633464
- Deposit date:
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2016-08-18
Terms of use
- Copyright holder:
- Hay et al
- Copyright date:
- 2016
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from Nature Publishing Group at: https://doi.org/10.1038/ng.3605
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