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Genetic dissection of the α-globin super-enhancer in vivo

Abstract:

Many genes determining cell identity are regulated by clusters of Mediator-bound enhancer elements collectively referred to as super-enhancers. These super-enhancers have been proposed to manifest higher-order properties important in development and disease. Here we report a comprehensive functional dissection of one of the strongest putative super-enhancers in erythroid cells. By generating a series of mouse models, deleting each of the five regulatory elements of the α-globin super-enhancer...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1038/ng.3605

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Department:
Jesus College
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Department:
Oxford, MSD, RDM, Weatherall Insti. of Molecular Medicine
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Department:
Oxford, MSD, RDM, Weatherall Insti. of Molecular Medicine
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Department:
Oxford, MSD, RDM, RDM Clinical Laboratory Sciences
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Department:
Oxford, MSD, RDM, Weatherall Insti. of Molecular Medicine
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Funding agency for:
Hay, Deborah
Wellcome Trust More from this funder
Medical Research Council More from this funder
National Institute for Health Research Biomedical Research Council, Oxford More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Genetics Journal website
Volume:
48
Issue:
8
Pages:
895-903
Publication date:
2016-08-01
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
Pubs id:
pubs:633464
URN:
uri:70d2690b-fcde-48ee-9be5-982faa0ab220
UUID:
70d2690b-fcde-48ee-9be5-982faa0ab220
Local pid:
pubs:633464
Language:
English
Keywords:

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